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Life is a resource in Magic: The Gathering, like anything else, so be sure to spend it if you feel like it will draw you into your game-winning card or combo
Some of the more sought after (read: expensive) cards on this list are: The original five Phyrexian Praetors Ragavan, Nimble Pilferer Atraxa, Praetors' Voice Skithiryx, the Blight Dragon The Brothers' War The Brothers War was the first official printing of serialized cards, and it was hot out of the gates with all 63 of the cards on the Retro Artifacts bonus sheet included in their sketch printings
Payoffs like Haruspex, Deathbringer Thoctar, Sadistic Glee or Blade of the Bloodchief can even trigger off opposing permanents, which makes them nasty for multiplayer even if your own engine is completely stalled
They religiously track the rise of and fall of format staples, hoping that their garage full of sparkly bits of cardboard will buy them a house in 20 years time, completely ignoring the games they could be enjoying with them